Claude 在 Claude Science 中自主设计针对蝎神经毒素的蛋白质结合剂
Anthropic 的 Claude 在 Claude Science 环境中基本自主设计了针对蝎神经毒素的蛋白质结合剂。Claude 在 24 小时内生成了 318,484 个设计方案，经团队筛选与实验室测试，有 17 个设计方案符合结合剂标准，其中两个最强的方案与针对墨西哥蝎毒素 Cn2 的已知抗体结合位点高度接近。外部专家认为这是有前景的第一步，独立实验室也对结果进行了验证。
Anthropic's Claude largely autonomously designed protein binders targeting scorpion neurotoxins, which kill more than 3,250 people every year. These small protein molecules are shaped to latch onto a specific target molecule. Claude generated 318,484 designs for such protein binders targeting five toxins from four scorpion species. After an initial prompt, Claude worked on its own for 24 hours. The research team then steered the work with additional instructions.
Claude picked 180 candidates, and the team added 31 more. Of the 211 designs tested in the lab, 17 met the criteria for a binder. The two strongest bound extremely tightly to Cn2, a toxin from the Mexican scorpion. Lab tests suggest they dock at or near the same site as an antibody known to neutralize Cn2 in mice. Whether they actually work as an antivenom hasn't been tested yet.
External experts Susana Vázquez Torres and Timothy P. Jenkins called the work a promising first step. Two independent labs confirmed the results. Claude worked inside Claude Science, Anthropic's AI environment for researchers. In an earlier study, Claude had already designed mini-binders against 14 of 15 target proteins, with hit rates of 22 to 35 percent compared to the typical 10 to 15 percent.
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来源：The Decoder：AI News · the-decoder.com